Table 1.
Pharmacokinetic profiles of amlodipine after administration of a single dose of 5 mg amlodipine according to the genetic polymorphisms of the ABCB1 gene at positions 2677 and 3435
| Difference between genotypes | |||||||
|---|---|---|---|---|---|---|---|
| Parameter | 2677GG/3435CC | 2677GT/3435CT | 2677TT/3435TT | 2677GG/3435CC & 2677GT/3435CT | 2677GG/3435CC & 2677TT/3435TT | 2677GT/3435CT & 2677TT/3435TT | P-value |
| Cmax (ng ml−1) | 3.8 ± 0.5 | 3.2 ± 0.5 | 2.7 ± 0.5 | 0.6 | 1.2† | 0.5 | 0.006 |
| (95% CI) | (3.5, 4.1) | (2.6, 3.8) | (2.3, 3.1) | (−0.2, 1.4) | (0.4, 2.0) | (−0.3, 1.3) | |
| tmax (h) | 5 | 6 | 6 | 0.9 | −0.3 | −1.2 | 0.828 |
| (range) | (5.0–12.0) | (5.0–8.0) | (5.0–12.0) | (−1.7, 3.5) | (−3.0, 2.4) | (−3.9, 1.5) | |
| Half-life (h) | 51.8 ± 10.9 | 46.3 ± 7.1 | 43.0 ± 5.6 | 5.5 | 8.8 | 3.3 | 0.132 |
| (95% CI) | (44.7, 58.9) | (41.7, 50.9) | (39.1, 46.9) | (−4.6, 15.6) | (−1.6, 19.2) | (−7.1, 13.7) | |
| AUClast (ng h−1 ml−1) | 180.9 ± 29.0 | 133.6 ± 33.1 | 125.1 ± 33.0 | 47.3* | 55.9† | 8.5 | 0.003 |
| (95% CI) | (161.9, 199.9) | (111.9, 155.3) | (102.2, 148.0) | (8.7, 85.9) | (16.1, 95.7) | (−31.3, 48.3) | |
| AUCinf (ng h−1 ml−1) | 208.6 ± 39.2 | 149.8 ± 40.1 | 140.8 ± 35.6 | 58.8† | 67.8† | 9.0 | 0.002 |
| (95% CI) | (183.0, 234.2) | (123.6, 176.0) | (116.1, 165.5) | (12.0, 105.6) | (19.6, 116.0) | (−39.2, 57.2) | |
| CL/F (l h−1) | 24.8 ± 5.4 | 35.7 ± 9.9 | 37.7 ± 10.2 | −10.9* | −12.9* | −2.1 | 0.010 |
| (95% CI) | (21.3, 28.3) | (29.2, 42.2) | (30.6, 44.8) | (−21.5, −0.3) | (−23.8, −2.0) | (−13.0, 8.8) | |
Data are shown as mean ± SD. tmax is given as median (range). Cmax, Peak plasma concentration; tmax, time to Cmax; AUClast, area under the time–concentration curve from 0 to 144 h; AUCinf, area under the time–concentration curve from 0 to infinity; CL/F, oral clearance.
*
P < 0.05 by anova with Bonferroni correction a posteriori for wild-type group
†
P < 0.01 by anova with Bonferroni correction a posteriori for wild-type group.