Table 1.
Pharmacokinetic parameters following single-dose administration of cysteamine to different gastrointestinal sites in healthy volunteers
| Parameter | Stomach (n = 8) | Small Intestine (n = 8) | Caecum (n = 4) | Mid-ileum (n = 2) |
|---|---|---|---|---|
| λZ (h-1) | 0.0086 (0.0030) | 0.0070 (0.0028) | 0.0259 (0.0350) | 0.0057 (0.0011) |
| t1/2 (min) | 94.5 (48.0) | 112.7 (42.5) | 98.3 (46.5) | 124.6 (23.3) |
| AUC(0,tlast) (min × µm) | 3613.3 (1383.5) | 3987.8 (1659.0) | 2804.2 (1323.0) | 4215.1 (1048.5) |
| AUC(0, ∞) (min × µm) | 3901.9 (1591.9) | 4331.3 (1907.6) | 3141.4 (1627.6) | 4556.4 (947.7) |
| %AUCextrap | 6.4 (5.2) | 6.8 (5.0) | 8.6 (5.6) | 7.9 (3.8) |
| tmax (min) | 50a (26) | 21b (6) | 64a (26) | 30 0 |
| Cmax (µm) | 39a,b (16) | 51a (21) | 23b (15) | 48.9 (14.4) |
Standard deviations listed in parentheses.
a,b
Within-group mean values with non-matching superscripts are significantly different (P < 0.05). Data from mid-ileum cysteamine infusion were not included in the statistical analysis.