Table 1.
Dexamphetamine concentrations in milk and plasma, milk to plasma (M/P) values, maternal and infant doses and infant plasma concentrations
| Mother– infant pair | Milk Cmax (µg l−1) | Milk Cav (µg l−1) | Plasma Csingle or Cav (µg l−1) | M/P* | Maternal dose (µg kg−1 day−1) | Absolute infant dose (µg kg−1 day−1) | Relative infant dose (%) | Infant plasma concentration (µg l−1) |
|---|---|---|---|---|---|---|---|---|
| A | 112 | 66 | 34 | 1.9 | 259 | 10 | 3.9 | 2 |
| B | 486 | 313 | 131 | 2.4 | 643 | 47 | 7.3 | 18 |
| C | 325 | 206 | 41 | 4.2 | 224 | 31 | 13.8 | ND |
| D | 86 | 73 | 14 | 5.3 | 274 | 11 | 4.0 | <1 |
| Median | 219 | 140 | 38 | 3.3 | 267 | 21 | 5.7 | |
| (IQR) | (99–406) | (70–260) | (24–86) | (2.2–4.8) | (242–459) | (11–39) | (4–10.6) |
*
M/P calculated from AUC data for patients A and B and from single paired data for patients C and D; ND, no plasma sample available.