Table 1.
Maternal dose of mirtazapine, absolute and relative infant doses and infant plasma concentrations of mirtazapine and desmethylmirtazapine
| Mirtazapine | Desmethylmirtazapine | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Patient | Maternal dose (µg kg−1 day1) | Absolute infant dose (µg kg−1 day−1) | Relative infant dose (%) | Infant plasma concentration (µg l−1)‡ | Absolute infant dose (µg kg−1 day −1) | Relative infant dose (%) | Infant plasma concentration (µg l−1)‡ | Total relative infant dose*(%) | |
| 1 | 536 | 10.0 | Relative infant dose (%) | 1.9 | <1 | 2.7 | 0.5 | <1 | 2.4 |
| 2 | 1967 | 11.2 | 0.6 | 1.5 | 2.5 | 0.1 | <1 | 0.7 | |
| 3 | 474 | 6.0 | 1.3 | <4 | 1.1 | 0.2 | <3 | 1.5 | |
| 4 | 857 | 7.2 | 0.8 | <1 | 2.6 | 0.3 | <1 | 1.2 | |
| 5 | 309 | 7.7 | 2.5 | ND | 1.9 | 0.7 | ND | 3.1 | |
| 6 | 353 | 9.8 | 2.8 | ND | 1.5 | 0.4 | ND | 3.1 | |
| 7 | 517 | 5.1 | 1.0 | ND | 0.9 | 0.2 | ND | 1.2 | |
| 8 | 462 | 7.1 | 1.5 | ND | 2.3 | 0.5 | ND | 2.1 | |
| Mean | 495 | 8.0 | 1.5 | 3.0 | 0.4 | 1.9 | |||
| (95%CI) | (407, 696)† | (6.8, 9.8) | (0.8, 2.2) | (2.4, 3.6) | (0.2, 0.6) | (1.1, 2.7) | |||
ND, No plasma sample available.
*
Expressed in mirtazapine equivalents.
†
Median (25th & 75th percentiles).
‡
Higher limits of detection for some samples as a result of sample volume available for assay.