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Parameter estimates in the final model
| parameter | Estimate | SE | ω (CV) |
|---|---|---|---|
| θCL0 (l day−1) | 44.1 | 2.3 | 35% |
| θT50 (28 days) | 23.8 | 4.4 | 109% |
| β | 1.00 | Fixed | – |
| θCLcr | 0.21 | 0.090 | – |
| Ka (day−1) | 1.90 | Fixed | – |
| V (l) | 149.0 | 12.1 | 59% |
| σɛ (l day−1) | 41.4 ± 84.2% | – | – |
ω, Intersubject variability; SE, standard error; CV, coefficient of variation;θCL0, incept term in baseline;θT50, time for baseline clearance decline to 1/2 ofθ CL0;β, steepness parameter; Ka, absorption rate constant;σɛ residual variability.
