Table 1.
lassification of low and high doses of β-blocker, angiotensin-converting enzyme inhibitors (ACEI), spironolactone and loop diuretics
| Dose range (mg day−1) | ||
|---|---|---|
| Drug (Reference) | Low dose | High dose |
| β-Blockers | ||
| Carvedilol | <25 | ≥25 |
| Metroprolol | <100 | ≥100 |
| Bisoprolol | <5 | ≥5 |
| Nebivolol | <5 | ≥5 |
| Labetalol | <1200 | ≥1200 |
| Propranolol | <80 | ≥80 |
| Atenolol | <50 | ≥50 |
| ACEIs | ||
| Enalapril | <10 | ≥10 |
| Captopril | <75 | ≥75 |
| Lisinopril | <10 | ≥10 |
| Fosinopril | <10 | ≥10 |
| Quinapril | <20 | ≥20 |
| Perindopril | <4 | ≥4 |
| Ramipril | <5 | ≥5 |
| Loop diuretics | ||
| Furosemide | ≤80 | >80 |
| Bumetanide | ≤2 | >2 |
| Spironolactone | ≤25 | >25 |
A low dose of β-blocker and ACEI is defined as <50% of the target dose attained in randomized clinical trials. A low dose of spironolactone is defined as ≤50% of the target dose attained in randomized clinical trials. A low dose of loop diuretics is defined as furosemide ≤80 mg, bumetanide ≤2 mg.