Table 4.
Examples of well-established CYP 3A4 substrates for which there are not yet case reports or clinical studies which show a clinically significant herb–drug interaction with the potent CYP 3A4 inducer St John's wort [40, 41]
| Drug class | Drug(s) |
|---|---|
| Anti-arhythmics | Quinidine |
| Antimalarials | Mefloquine |
| Quinine | |
| Calcium channel blockers | Nifedipine |
| Verapamil | |
| HIV protease inhibitors | Nelfinavir* |
| Ritonavir* | |
| Saquinavir* | |
| HMG CoA reductase inhibitors | Atorvastatin |
| Fluvastatin | |
| Lovastatin |
*
While these drugs are listed in the Appendix on Interactions of the British National Formulary as drugs that can interact with St John's wort [42], the other drugs in this Table are not.