Appendix 1.

Individual trial results

	High dose of analgesic			Low dose of analgesic
	Number of patients >50%			Number of patients >50%
Reference [number]	maxTOTPAR	Total	percent	maxTOTPAR	Total	percent
Aspirin 1000 mg vs 500 mg
Ahlstrom 1974 [14]	14	46	30	8	51	16
Steiner 2003 [28]	78	103	76	71	101	70
Aspirin 1200 mg vs 600 mg
Fucella 1977 [18]	16	27	59	14	31	45
Mahler 1976 [22]	14	30	47	9	29	31
Mahler 1976 [22]	4	11	36	5	10	50
Parkhouse 1968 [23]	51	125	41	46	125	37
Forbes 1990 [17]	17	71	24	17	68	25
London 1983 [21]	17	40	43	13	41	32
Ibuprofen 800 mg vs 400 mg
Cooper 1977 [16]	18	40	45	15	38	39
Jain 1986 [43]	45	49	92	41	47	87
Cooper 1984 study4 [33]	24	28	86	20	24	83
Hersh 2000 [39]	47	59	80	43	61	70
Hersh 1993 [38]	19	49	39	14	51	27
McQuay 1996 [43]	6	30	20	2	31	6
Dionne and McCullagh 1998 [35]	35	50	70	31	51	61
Schou 1998 [44]	41	49	84	36	49	73
Cooper 86 s4 [34]	31	45	69	26	34	76
Cooper 86 S5 [34]	22	31	71	23	32	72
Bostrom 94 [32]	29	40	73	16	40	40
Seymour 96 [45]	11	15	73	7	18	39
Serymour 96 [45]	12	16	75	10	17	59
Paracetamol 1000 vs 500/650
Laska 1983 study 1 [49]	29	50	58	25	54	47
Laska study 2 [49]	41	68	61	39	68	58
Laska study 3 [49]	49	81	61	46	81	56
McQuay 1986 [50]	13	30	44	9	30	30
Ragot 1991 [52]	14	40	35	13	40	33
Steiner 2003 [28]	79	111	71	61	105	58
Hopkinson 1974 [48]	71	87	82	51	88	58