Table 2.
Comparison of MPA pharmacokinetic parameters between renal allograft recipients with normal and delayed gastric emptying, as measured with the 13C-glycine breath test for fluids
| 13C-glycine breath test | |||||
|---|---|---|---|---|---|
| Normal (n = 11) | Delayed (n = 15) | P-value | Mean difference (95% CI) | ||
| MPA | C0 (mg l−1) | 2.0 (1.3–8.5) | 2.4 (1.71–6.1) | NS | +0.04 (−1.4, +1.5) |
| Dose-corrected C0 (mg l−1 g−1) | 3.99 (2.5–17.1) | 4.43 (1.8–24.3) | NS | +0.23 (−4.0, +4.4) | |
| Cmax (mg l−1) | 20.1 (10.7–28.5) | 10.6 (6.5–21.3) | 0.0075 | −6.5 (−2.1, −10.9) | |
| Dose-corrected Cmax (mg l−1 g−1) | 40.1 (21.4–57.0) | 19.8 (7.0–42.2) | 0.0028 | −14.9 (−5.8, −24.0) | |
| tmax (h) | 0.5 (0.33–1) | 1.0 (0.33–2) | 0.0289 | +0.39 (+0.03, +0.75) | |
| AUC0−4 (mg h−1 l−1) | 22.4 (13.1–29.8) | 20.4 (13.9–43.0) | NS | +1.67 (−4.1, +7.5) | |
| Dose-corrected AUC0−4 (mg h−1 l−1 g−1) | 44.8 (26.2–59.5) | 38.7 (20.4–99.2) | NS | −0.86 (−14.0, +12.3) | |
| AUC0−12 (mg h−1 l−1) | 26.3 (18.3–55.3) | 30.2 (14.3–62.6) | NS | +0.82 (−11.8, +13.5) | |
| Dose-corrected AUC0−12 (mg h−1 l−1 g−1) | 52.7 (36.6–111) | 57.8 (28.0–125) | NS | −3.31 (−30.2, +23.5) | |
| CL/F (l h−1) | 19.0 (9.0–27.3) | 17.3 (8.0–35.8) | NS | −6.51 (−28.0, +15.0) | |
| CL/F/kg (l h−1 kg−1) | 0.25 (0.12–0.57) | 0.22 (0.09–0.63) | NS | −0.11 (−0.44, +0.21) | |
| MPAG | C0 (mg l−1) | 49.1 (26.5–68.4) | 53.8 (32.2–121) | NS | +11.1 (−73.0, +29.5) |
| AUC0−4 (mg h−1 l−1) | 254 (209–353) | 264 (174–457) | NS | +21.5 (−42.2, +85.1) | |
| Dose-corrected AUC0−4 (mg h−1 l−1 g−1) | 508 (418–705) | 457 (328–1589) | NS | +30.3 (−185, +245) | |
| Cmax (mg l−1) | 72.7 (64.3–102) | 84.7 (45.8–123) | NS | +7.0 (−10.7, +24.7) | |
| tmax (h) | 1.0 (0.5–2) | 2.0 (0.5–4) | 0.0040 | +1.0 (+0.32, +1.70) | |
Data are expressed as median and range.