Table 1.
Demographic and baseline characteristics of hypertensive patients characterized as extensive (EMs) and poor (PMs) metabolizers of CYP2D6 (means ± SD)
| EMs, n = 23 | PMs, n = 14 | |
|---|---|---|
| Age, years (range) | 56.2 ± 7.6 (45–64) | 54.6 ± 8.3 (36–70) |
| Sex, male/female | 12/11 | 8/6 |
| Body weight, kg | 79.1 ± 13.8 | 82.1 ± 13.6 |
| Dextromethorphan to dextrorphan ratio | 0.0020–0.1818 | 0.3333–6.6667 |
| Genotype frequencies | 13 CYP2D6*1/*4 | 5 CYP2D6*4/*4 |
| 9 CYP2D6*1/*1 | 3 CYP2D6*4/*3 | |
| 1 CYP2D6*1/*5 | 3 CYP2D6*4/*5 | |
| 2 CYP2D6*5/*5 | ||
| 1 CYP2D6*4/*6 | ||
| Serum creatinine, µmol l−1 | 79.4 ± 14.1 | 76.9 ± 15.8 |
| Sitting systolic BP, mmHg | 157.7 ± 16.6 | 154.8 ± 17.4 |
| Sitting diastolic BP, mmHg | 101.3 ± 5.1 | 103.3 ± 4.2 |
| Sitting heart rate, beats min−1 | 71.7 ± 6.6 | 70.6 ± 5.6 |
BP, Blood pressure.