Table 3.
Relative metabolite concentrations in plasma samples of the T2DM patients and HVs collected during the run-in period (visits 1 and 2)
| Metabolite | Chemical shift (multiplicity) | T2DM vs. HVs |
|---|---|---|
| Leucine | 0.95 (t), 0.97 (d), 1.74 (m) | ↓ |
| Isoleucine | 1.00 (d), 3.67 | ↓ |
| Valine | 1.05 (d), 3.61 | ↓ |
| 3-D-hydroxybutyrate | 1.20 | ↓ |
| Methylene groups from mobile fatty | 1.29 (m) | ↑ |
| acids in lipoproteins | ||
| Lactate | 1.33 (d) | ↑ |
| Alanine | 1.48 (d) | ↓ |
| Lipid (C[H2]-CH2-CO) | 1.59 (m), 5.33 | ↑ |
| Glutamine | 2.14 (m), 2.45 (m) | ↓ |
| Lipid (CH2-CO) | 2.25 (m) | ↑ |
| Citrate | 2.55 and 2.67 (dd) | ↓ |
| Lipid (C = C-CH2-C = C) | 2.76 (m) | ↑ |
| Tyrosine | 3.06, 3.94, 6.92 (d), 7.20 (d), | ↓ |
| Formate | 8.48 (s) | ↓ |
The up and down arrows indicate a respective increased or decreased concentration of each metabolite in the T2DM vs. HV group. Where multiplicity is indicated, s = singlet; d = doublet; t = triplet; dd = doublet of doublets; m = multiplet. T2DM, Type 2 diabetes mellitus; HV, healthy volunteer.