Table 4.
Relative metabolite differences of the T2DM patients and HVs in urine samples samples collected during the run-in period (visits 1 and 2)
| Metabolite | Chemical shift (multiplicity) | T2DMvs. HV |
|---|---|---|
| Alanine | 1.48 (d) | ↑ |
| Glutamate | 2.10 (m), 2.39 (m), 2.50 (m) | ↓ |
| Glutamine | 2.12 (m) | ↓ |
| Citrate | 2.57 and 2.72 (dd) | ↑ |
| Phenylalanine | 3.12 (m), 3.27 (m), 4.00 (m), 7.30 (m), | ↑ |
| 7.38 (m), 7.42 (m) | ||
| Tyrosine | 3.20 (dd), 3.32 (dd), 6.90 (d), 7.20 (d) | ↑ |
| Hippurate | 3.97 (d), 7.56 (t), 7.65 (t), 7.84 (d) | ↑ |
| N-methyl nicotinamide | 4.49 (s), 8.91 (d), 8.99 (d), 9.30 (s) | ↓ |
| Phospho(enol)pyruvate | 5.19 (t), 5.36 (t) | ↑ |
| Uridine | 5.81 (d), 5.87 (d), 7.78 (d) | ↓ |
The up and down arrows indicate a respective increased or decreased concentration of each metabolite in the T2DM vs. HV group. Where multiplicity is indicated, s = singlet; d = doublet; t = triplet; dd = doublet of doublets; m = multiplet. T2DM, Type 2 diabetes mellitus; HV, healthy volunteer.