Table 2.

Mean pharmacokinetics of R667 following multiple-dose oral administration of 0.2, 0.5, or 1 mg of R667 to emphysematous patients

Parameter (units)	Dose (mg)	n	Mean ± SD	Min	Max	CV (%)
Cmax (ng ml−1)	0.2	9	1.80 ± 1.10	0.81	4.04	61.1
	0.5	10	4.84 ± 2.57	2.91	9.72	53.1
	1	10	10.3 ± 3.59	5.34	15.6	34.9
tmax (h)	0.2	9	3.92 ± 2.34	1.07	8.03	59.6
	0.5	10	4.09 ± 2.05	1.80	8.00	50.2
	1	10	4.02 ± 2.41	1.00	8.00	59.9
AUC(0,τ) (ng ml−1 h)	0.2	9	10.3 ± 3.23	5.81	15.0	31.3
	0.5	10	29.0 ± 12.4	15.8	51.6	42.7
	1	10	57.7 ± 12.6	35.4	78.7	21.8
CL/F (l h−1)	0.2	9	21.3 ± 7.46	13.3	34.4	35.0
	0.5	10	20.4 ± 8.40	9.70	31.7	41.3
	1	10	18.2 ± 4.40	12.7	28.3	24.2

SD. = standard deviation. CV = coefficient of variation.