Table 3.

C_max ratios of metabolites to R667 following multiple-dose oral administration of 0.2, 0.5, or 1 mg of R667 to emphysematous patients

Cmax ratio	R667 (mg)	n	Mean ± SD	Min	Max	CV (%)
M2:R667a	0.2	9	0.206 ± 0.0699	0.108	0.322	33.9
	0.5	10	0.239 ± 0.0769	0.143	0.345	32.2
	1	10	0.212 ± 0.0632	0.124	0.338	29.9
M3:R667b	0.2	9	0.551 ± 0.278	0.217	0.992	50.4
	0.5	10	0.562 ± 0.254	0.213	1.00	45.2
	1	10	0.475 ± 0.256	0.271	1.06	53.8
M4a:R667c	0.2	9	0.167 ± 0.135	0.0600	0.469	80.7
	0.5	10	0.218 ± 0.111	0.0590	0.413	50.8
	1	10	0.184 ± 0.0822	0.107	0.306	44.6
M4b:R667d	0.2	9	0.241 ± 0.135	0.0810	0.42	56.1
	0.5	10	0.337 ± 0.162	0.0470	0.559	48.0
	1	10	0.303 ± 0.184	0.131	0.610	60.7

^aCalculated metabolite M2:R667 ratio.

^bCalculated metabolite M3:R667 ratio.

^cCalculated metabolite M4a:R667 ratio.

^dCalculated metabolite M4b:R667 ratio.