Table 3.

Population estimated model parameters and related information

PK/PD parameter	Population mean [θ (SE for θ)]	Interindividual variance (ω,% CV)
CLx/f (ml h−1)*	7.32 (0.153)	20.3
CLX/f exponent for body weight	0.911 (0.135)
ΔCLC/f (ml h−1)	5.86 (0.920)	34.9
CLE/f (ml h−1)†	71.0 (4.68)	25.3
CLE/f exponent for baseline IgE	−0.281 (0.0312)
PE/f (µg h−1)†	30.3 (2.04)	23.1
PE/f exponent for baseline IgE	0.657 (0.0301)
Correlation between η(CLE/f) and η(PE/f)	0.968
VX/f (ml)*‡	5900 (107)	13.0
VX/f exponent for body weight	0.658 (0.100)
VC/f (ml)	3630 (223)	25.0
ka (h−1)	0.0200 (0.00114)	39.9
Kd0 (nm)	1.07 (0.118)
α	0.157 (0.0306)
		Intra-individual variance (σ,% CV)
Omalizumab		16.7
Total IgE		21.1
Free IgE		21.8

NONMEM objective function value: 37375.330. Total no. of observation records: 3192. Total no. of individuals: 202.

^*The value at 61.1 kg of body weight.

^†The value at 482.4 ng ml⁻¹ of baseline IgE (30.3 µg h⁻¹ = 0.159 nmol h⁻¹).

^‡V_E/f was assumed to be the same as V_X/f.