. Author manuscript; available in PMC: 2007 Oct 4.

Published in final edited form as: Nat Genet. 2005 Jul 17;37(8):863–867. doi: 10.1038/ng1604

Table 2. Haplotype analysis of 1225 morbidly obese/obese children and 1205 control subjects.

Haplotypes comprising three polymorphisms (K121Q, IVS20 delT-11, A>G+1044 TGA) are shown. TDT was performed for each haplotype in 97 pedigrees with childhood obesity and in 87 pedigrees with adult obesity.

Haplotypes			Case/control Test				TDT in 184 obesity pedigrees
K121Q	IVS20delT-11	A>G+1044TGA	Non obese	Obese	Chi-square	p-value	Chi-square	p-value
K	T	A	64.0	60.3	8.99	0.003	2.7	0.1
	T	G	7.0	7.6	0.51	0.47	0.09	0.75
	DelT	A	3.5	2.7	1.26	0.26	0	1
	DelT	G	11.7	11.9	0.18	0.67	0.73	0.39
Q	T	A	5.5	4.8	0.15	0.70	2.30	0.13
	T	G	0.6	0.6	0.19	0.66	0	1
	DelT	A	0.2	0.9	5.23	0.02	0.20	0.65
	DelT	G	7.5	11.2	18.78	0.00001	5.68	0.01