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. 2007 Oct 11;117(11):3445–3452. doi: 10.1172/JCI32729

Figure 2. VavNULL mice exhibit severely compromised host defense against bacterial pneumonia.

Figure 2

(A and B) WT and VavNULL bone marrow–derived neutrophils were stimulated with P. aeruginosa (A) or S. aureus (B) and monitored for oxidative burst by lucigenin chemiluminescence. (C) WT and VavNULL mice were infected with P. aeruginosa by intratracheal instillation, and mouse viability was monitored over 7 days. n = 5 per group. P < 0.002. (D) After intratracheal infection with S. aureus, WT and VavNULL mice were sacrificed at 20 hours, and BAL was collected for quantitation of bacterial load in the lungs. n = 5 per group. P < 0.016.