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. Author manuscript; available in PMC: 2007 Oct 4.
Published in final edited form as: FEBS Lett. 2007 Jul 19;581(20):3809–3813. doi: 10.1016/j.febslet.2007.07.003

Figure 1.

Figure 1

A schematic diagram of APP. The amyloid β peptide (Aβ) region contains part of the transmembrane domain (black box) and part of the extracellular domain of APP (green box). Cleavage by β-secretase generates the N terminus, and intramembranous cleavage by γ-secretase gives rise to the C terminus of Aβ. Cleavage by α-secretase precludes Aβ formation. Eleven missense mutations in the transmembrane region of APP are shown, together with the suggested cleavage sites for ε- and ξ-secretases. Red letters indicate mutations tested here.