Table 3.
Age and Race-Adjusted Cross-Sectional Association of MI and Stroke with High Leptin and the Traditional Cardiovascular Risk Factors in Men
| MI/ Stroke | MI | Stroke | |||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P Value | OR | 95% CI | P Value | OR | 95% CI | P Value | |
| Dyslipidemia | 1.93 | 1.41-2.65 | <0.0001 | 2.21 | 1.54-3.23 | <0.0001 | 1.55 | 0.97-2.49 | 0.0656 |
| Hypertension | 2.06 | 1.47-2.92 | <0.0001 | 1.79 | 1.22-2.65 | 0.0030 | 2.17 | 1.27-3.85 | 0.0055 |
| Diabetes | 1.80 | 1.24-2.58 | 0.0015 | 1.71 | 1.12-2.57 | 0.0105 | 1.55 | 0.88-2.62 | 0.1067 |
| Smoking | 1.60 | 1.14-2.29 | 0.0076 | 1.83 | 1.22-2.80 | 0.0039 | 1.35 | 0.81-2.31 | 0.2539 |
| High leptin | 2.49 | 1.52-4.22 | 0.0004 | 2.62 | 1.48-4.91 | 0.0015 | 1.76 | 0.86-3.92 | 0.1368 |
| High leptin/BMI ratio | 2.04 | 1.27-3.37 | 0.0039 | 1.99 | 1.16-3.58 | 0.0153 | 1.98 | 0.95-4.54 | 0.0821 |
| Adjusted-High leptin* | 2.41 | 1.20-4.93 | 0.0139 | 3.16 | 1.40-7.37 | 0.0061 | 1.37 | 0.48-3.88 | 0.5462 |
*
Adjusted for Age, Race plus Dyslipidemia, Hypertension, Diabetes, Smoking and Obese status
High leptin was defined as the highest quartile of serum leptin (> 7.5 in men) when compared to the lowest quartile.