Table 4.
Age and Race-Adjusted Cross-Sectional Association of MI and Stroke with High Leptin and the Traditional Cardiovascular Risk Factors in Women
| MI/ Stroke | MI | Stroke | |||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P Value | OR | 95% CI | P Value | OR | 95% CI | P Value | |
| Dyslipidemia | 1.76 | 1.18-2.67 | 0.0060 | 1.56 | 0.94-2.69 | 0.0903 | 1.97 | 1.17-3.45 | 0.0128 |
| Hypertension | 1.88 | 1.21-3.00 | 0.0057 | 1.36 | 0.78-2.46 | 0.2784 | 2.07 | 1.16-3.88 | 0.0165 |
| Diabetes | 2.90 | 1.89-4.38 | <0.0001 | 2.28 | 1.28-3.92 | 0.0038 | 2.87 | 1.64-4.77 | <0.0001 |
| Smoking | 1.84 | 1.26-2.67 | 0.0014 | 1.97 | 1.21-3.22 | 0.0061 | 1.66 | 1.02-2.69 | 0.0364 |
| High leptin | 3.42 | 2.01-6.03 | <0.0001 | 3.29 | 1.65-7.08 | 0.0012 | 3.22 | 1.65-6.69 | 0.0009 |
| High leptin/BMI ratio | 2.89 | 1.72-5.00 | <0.0001 | 3.11 | 1.58-6.53 | 0.0016 | 2.56 | 1.33-5.16 | 0.0061 |
| Adjusted-High leptin* | 4.26 | 1.75-10.73 | 0.0016 | 3.96 | 1.29-12.72 | 0.0178 | 3.20 | 1.04-10.54 | 0.0474 |
*
Adjusted for Age, Race plus Dyslipidemia, Hypertension, Diabetes, Smoking and Obese status
High leptin was defined as the highest quartile of serum leptin (>23.5 in women) when compared to the lowest quartile.