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Arrangement of the CNBDs in the constructed model. (a) A vertical arrangement of the CNBDs fits best into the determined 3D structure. (b) The horizontal arrangement of the CNBDs as in the HCN2 CNBD crystal structure cannot satisfyingly be docked into the 3D volume. S1-S4 helices, blue; S5-S6, yellow, CNBD, red. Scale bar 5 nm.
