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. Author manuscript; available in PMC: 2007 Oct 4.
Published in final edited form as: Neuroscience. 2007 Jul 19;148(1):198–211. doi: 10.1016/j.neuroscience.2007.04.062

Figure 6.

Figure 6

Mutually exclusive cellular localization of PARP-1 and PARG. Confocal laser scanning microscopy analysis of PARP-1 and PARG in rat neuronal cortical cultures. Upper panels: Mixed neuronal cultures were stained with mouse α–PARP-1, α–Cyt C, rabbit α–PARG and with the DNA binding dye TOTO-3. Lower panels: Mixed neuronal cortical cultures were stained with rabbit α–PARG and mouse α–GFAP (glial marker) or α–MAP2 (neuronal marker). Confocal laser scanning microscopy shows that PARP-1 and PARG display a mutually exclusive cellular localization and that PARG is expressed in both neurons and astrocytes.