Table 5.
Comparison of the Site I and II ligand-binding domains within each IRBP module
| Amino acid residues lining the two domains: | ||||||||||||||
| Site I | Site II | |||||||||||||
| X1: | W132 | Y162 | V97 | I111 | L127 | I131 | L109 | W268 | P63 | S271 | G236 | Y73 | T240 | L238 |
| X2: | W135 | Y165 | F100 | F114 | I130 | V134 | L112 | W272 | P62 | G275 | N241 | L73 | S245 | M243 |
| X3: | W133 | Y163 | F98 | F112 | L128 | V132 | L110 | W271 | H63 | S274 | V239 | E75 | V243 | L241 |
| X4: | W127 | Y157 | F92 | F106 | L122 | V126 | I104 | W265 | F55 | L268 | L233 | S66 | P237 | H235 |
| Amino acid residues that are significantly different and/or interfering with ligand-binding: | ||||||||||||||
| Site I | Site II | |||||||||||||
| X1: | V159 | M191 | E189 | E121 | L187 | Y73 | P76 | |||||||
| X2: | L162 | L196 | K194 | A124 | H192 | L73 | P76 | |||||||
| X3: | F160 | F194 | E192 | K122 | L190 | E75 | L77 | |||||||
| X4: | F154 | V188 | D186 | N116 | L184 | S66 | R69 | |||||||