Figure 8.

Anti-metastatic effect of bestatin treatment in SKOV-3 cells. A representative example of nude mice 30 days after i.p. inoculation of 1.0 × 10⁷ of SKOV-3 cells with or without subsequent daily treatment with bestatin, showing a mouse treated with PBS alone (a; left) or with bestatin (20 mg/kg, daily)(b; right). More apparent symptoms of carcinomatous peritonitis were observed in mice treated with PBS alone than in those treated with bestatin. In this experiment, each group consisted of seven mice.