Table 2.
Correlation among APN/CD13 expression, migratory potential, and MMP-2 activity in OVCA cell lines
| APN/CD13a expression | Migratoryb cell counts | MMP-2c activity | Doubling time (h) | Morphology | |
| ES-2 | 987.3 | 168 ± 22 | 34.2 ± 4.8 | 18.6 ± 3.7 | Fibroblastic |
| HEY | 692.6 | 153 ± 19 | 31.5 ± 5.1 | 22.3 ± 2.4 | Fibroblastic |
| SKOV-3 | 65.2 | 125 ± 23 | 23.9 ± 3.9 | 18.6 ± 4.7 | Fibroblastic |
| HRA | 4.5 | 129 ± 7 | 1.9 ± 0.9 | 17.4 ± 2.6 | Fibroblastic |
| TAOV | 7.4 | 22 ± 8 | 3.2 ± 2.1 | 20.2 ± 3.2 | Epithelioid |
| NOS2 | 5.0 | 11 ± 4 | 1.6 ± 1.2 | 18.9 ± 3.7 | Epithelioid |
| NOS4 | 3.8 | 17 ± 6 | 1.7 ± 0.9 | 19.4 ± 3.1 | Epithelioid |
a Mean fluorescence intensity by FACS analysis
b By Transwell migration assay × 200 HPF
c By ELISA assay in conditioned medium (ng/ml)