Table 1 Treatment subgroups and models in the experiments.
Experiment and cell type | Transplantation | |
---|---|---|
Normal heart (n = 19) | Infarcted heart (n = 27) | |
A: Histology: Differentiation of transplanted cells | ||
Cells: hESCs (n = 4), hEBs (n = 6) | 5 | 5 |
Scaffold + cells: hESCs (n = 3), hEBs (n = 4) | 4 | 3 |
Control: PBS (n = 4), PBS + scaffold (n = 2) | 3 | 3 |
B: Histology: Fate and outcome of transplanted hESCMs into intact rat heart | ||
hESCMs | 7 | |
C: Functional study: Transplantation of hESCMs after MI | ||
hESCMs (n = 8), PBS (n = 8) | 16 |
hEBs, human embryoid bodies; hESC, human embryonic stem cells; hESCM, human embryonic stem cell‐derived cardiomyocytes; MI, myocardial infarction; PBS, phosphate‐buffered saline.