Table 2 IHD in relation to RF and traditional IHD risk factors among 567 men and 589 women from the Hertfordshire Cohort Study.
| Men (n = 567) | Women (n = 589) | |||||
|---|---|---|---|---|---|---|
| IHD +ve No (%) | Unadjusted OR (95% CI) | Mutually adjusted OR (95% CI) | IHD +ve No (%) | Unadjusted OR (95% CI) | Mutually adjusted OR (95% CI) | |
| RF positive (⩾6 IU/ml vs <6 IU/ml) | 22 (23.9) | 3.1 (1.7 to 5.4) | 2.9 (1.6 to 5.3) | 8 (11.0) | 1.3 (0.6 to 2.8) | 1.3 (0.6 to 2.8) |
| Ex‐smoker vs never smoker | 39 (13.1) | 1.3 (0.7 to 2.4) | 1.2 (0.6 to 2.2) | 16 (9.5) | 1.1 (0.6 to 2.0) | 1.0 (0.5 to 1.9) |
| Current smoker vs never smoker | 9 (9.6) | 0.9 (0.4 to 2.2) | 1.0 (0.4 to 2.3) | 6 (9.8) | 1.1 (0.4 to 2.8) | 1.1 (0.4 to 2.9) |
| Family history of myocardial infarction* (yes vs no) | 13 (19.7) | 2.1 (1.1 to 4.1) | 1.9 (0.9 to 3.9) | 13 (12.3) | 1.5 (0.8 to 2.9) | 1.3 (0.7 to 2.6) |
| Previously/newly diagnosed diabetes (yes vs no) | 9 (23.1) | 2.5 (1.1 to 5.5) | 1.7 (0.7 to 4.1) | 6 (14.0) | 1.7 (0.7 to 4.2) | 1.2 (0.4 to 3.1) |
| High blood pressure (yes vs no) | 43 (22.3) | 4.4 (2.5 to 7.5) | 3.9 (2.2 to 6.8) | 32 (14.0) | 2.5 (1.4 to 4.5) | 2.3 (1.2 to 4.1) |
| BMI (z score increase) | – | 1.1 (0.9 to 1.5) | 1.0 (0.7 to 1.3) | – | 1.3 (1.0 to 1.7) | 1.2 (0.9 to 1.6) |
| Total fasting cholesterol (z score increase) | – | 0.8 (0.6 to 1.1) | – | – | 0.8 (0.6 to 1.1) | – |
| Total cholesterol:HDL ratio (z score decrease) | – | 1.1 (0.9 to 1.5) | 1.1 (0.8 to 1. 5) | – | 1.1 (0.8 to 1.4) | 1.0 (0.8 to 1.4) |
BMI, body mass index; HDL, high‐density lipoprotein; IHD, ischaemic heart disease; OR, odds ratio; RF, rheumatoid factor.
Total cholesterol and HDL:LDL ratio were correlated; HDL:LDL ratio was included in mutually adjusted models.
*Premature myocardial infarction in a first‐degree relative (before age 55 years in men, before age 65 years in women).