Table 3 Prevalence of IHD according to ANA, ACA and RF positivity, together with unadjusted and adjusted odds ratios for IHD.
| Antibody status | Men (n = 567) | Women (n = 589) | ||||
|---|---|---|---|---|---|---|
| n | No (%) with IHD | OR for IHD (95%CI) | n | No (%) with IHD | OR for IHD (95%CI) | |
| ACA* | ||||||
| –ve | 430 | 51 (11.9) | – | 473 | 41 (8.7) | – |
| +ve | 137 | 15 (10.9) | 0.9 (0.5 to1.7), p = 0.77 | 116 | 13 (11.2) | 1.3 (0.7 to 2.6), p = 0.40 |
| 1.1 (0.6 to 2.0), p = 0.81† | 1.3 (0.7 to 2.6), p = 0.41† | |||||
| ANA | ||||||
| –ve | 506 | 62 (12.3) | – | 517 | 50 (9.7) | – |
| +ve | 61 | 4 (6.6) | 0.5 (0.2 to1.4), p = 0.20 | 72 | 4 (5.6) | 0.6 (0.2 to1.6), p = 0.26 |
| 0.5 (0.2 to1.6), p = 0.25† | 0.6 (0.2 to1.6), p = 0.28† | |||||
| RF | ||||||
| –ve | 475 | 44 (9.3) | – | 516 | 46 (8.9) | – |
| +ve | 92 | 22 (23.9) | 3.1 (1.7 to 5.4), p<0.001 | 73 | 8 (11.0) | 1.3 (0.6 to 2.8), p = 0.57 |
| 2.9 (1.6 to 5.3), p<0.001† | 1.2 (0.5 to 2.8), p = 0.61† | |||||
ACA, anticardiolipin antibodies; ANA, antinuclear antibodies; IHD, ischaemic heart disease; OR, odds ratio; RF, rheumatoid factor.
*ACA positivity defined as the top octile from the IgG or IgM ELISA.
†Odds ratio adjusted for BMI, smoking status, family history of IHD, diabetes, high blood pressure and HDL:LDL ratio.