Figure 3. Contribution of PB1-F2 N66S Mutation to Pathogenicity of Recombinant Virus.
(A) Mice were inoculated with 1 × 104 PFU of virus or PBS, and their weights were recorded every day after infection.
(B) Virus titers from lung homogenates were measured from mice infected with WH or WH N66S virus at days 1, 2, 3, 5, 7, and 8 after inoculation. Error bars represent 1 standard deviation.
