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. 2007 Oct 5;3(10):e142. doi: 10.1371/journal.ppat.0030142

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© 2007 Manayani et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–D) Rats (four per group) were immunized with FHV-VWA_ANTXR2–PA₈₃ complex, FHV-VWA_ANTXR2 chimera alone, PA₈₃, or PBS and boosted 4 wk later. Serum samples were collected prior to as well as 3 and 7 wk after immunization and tested by ELISA for IgG-specific antibody response to (A) PA, (B)VWA_ANTXR2, and (C) FHV coat protein. Data represent the mean ± SD of animals in the respective groups and are shown for the 1:1,000 serum dilution in panels (A) and (B) and for the 1:100 serum dilution in panel (C). In panel (A) at week 3, * indicates p = 0.003 compared to PBS control and ** indicates p = 0.003 compared to PA₈₃ alone. At week 7, * indicates p = 0.005 compared to PBS control and ** indicates p = 0.012 compared to PA₈₃ alone. (D) Relationship between anti-PA antibody level and survival of individual rats following challenge with 10 MLDs of LeTx.

(E, F) Rats (five per group) were immunized once with FHV-VWA_ANTXR2–PA₈₃ complex, FHV-VWA_ANTXR2 chimera alone, PA₈₃, or PBS. Serum samples were collected prior to and 3 wk after immunization, diluted 1:100, and tested for IgG-specific antibody response to PA (E). Data represent the mean ± SD of animals in the repective groups. At week 3, * indicates p < 0.0001 compared to PBS control and ** indicates p = 0.001 compared to PA₈₃ alone. (F) Relationship between anti-PA antibody level and survival of individual rats following challenge with 10 MLDs of LeTx.