Table 2 Effect of multiple IVTA injections on visual acuity and central macular thickness over the course of the study.
| 1 injection, N = 6 | 2 injections, N = 8 | 3 injections, N = 13 | 4–5 injections, N = 6 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Δ | Mean (SD) | Δ | Mean (SD) | Δ | Mean (SD) | Δ | p* | |
| Visual acuity | |||||||||
| Baseline | 68.8 (6.4) | 61.6 (14.8) | 55.7 (12.8) | 60.3 (6.8) | 0.11 | ||||
| 6.9 | 5.4 | 8.7 | −3.0 | 0.05 | |||||
| 6 months | 75.7 (6.5) | 67.0 (18.9) | 64.4 (11.3) | 57.3 (5.3) | 0.31 | ||||
| −0.5 | −0.5 | −9.3 | −3.1 | 0.25 | |||||
| 12 months | 75.2 (7.4) | 66.5 (14.7) | 55.1 (14.8) | 54.2 (9.4) | 0.10 | ||||
| −1.2 | 0.5 | 2.5 | 6.0 | 0.65 | |||||
| 18 months | 74.0 (6.4) | 67.0 (16.2) | 57.6 (10.3) | 60.2 (11.8) | 0.02 | ||||
| 2.0 | −7.0 | 1.3 | 5.5 | 0.15 | |||||
| 24 months | 76.0 (8.6) | 60.0 (19.1) | 58.9 (11.7) | 65.7 (17.9) | 0.12 | ||||
| p (trend)† | 0.54 | 0.87 | 0.97 | 0.38 | |||||
| Final change | 7.2 | 0.14 | 7.8 | 6.3 | 0.44 | ||||
| p‡ | 0.02 | 0.98 | 0.006 | 0.47 | |||||
| Macular thickness | |||||||||
| Baseline | 405 (99) | 407 (74) | 503 (125) | 381 (161) | 0.36 | ||||
| 168 | 126 | 157 | 2 | 0.82 | |||||
| 6 months | 237 (51) | 281 (62) | 346 (152) | 379 (149) | 0.23 | ||||
| −35 | −40 | −6 | 43 | 0.99 | |||||
| 12 months | 272 (135) | 321 (104) | 352 (71) | 336 (147) | 0.23 | ||||
| 36 | 30 | −8 | 63 | 0.70 | |||||
| 18 months | 236 (53) | 291 (103) | 360 (140) | 293 (105) | 0.31 | ||||
| −3 | 9 | 72 | 48 | 0.70 | |||||
| 24 months | 239 (57) | 282 (126) | 288 (98) | 245 (43) | 0.62 | ||||
| p (trend)† | 0.01 | 0.06 | 0.002 | 0.12 | |||||
| Final change | 148 | 92 | 172 | 88 | 0.84 | ||||
| p‡ | 0.12 | 0.11 | 0.10 | 0.37 | |||||
Data are grouped according to number of injections received during the study; Δ, change between consecutive 6‐month visits. *p value compares injection categories adjusting for duration of diabetes and HbA1C; †p value compares trend in visual acuity over 24 months; ‡p value compares baseline and 24‐month visit.