Table 2 Comparison of the number of HLA‐DRB1 alleles in ON(MS+) patients and controls using the RPE method.

DRB1*	Controls vs ON (MS+) patients					<DRB1*15
	Controls (2n = 500)	Patients (2n = 86)	Expected* (2n = 86)	χ2	p	Patients (2n = 49)	Expected (2n = 49)	χ2*	p*
01	53	3	9.116	4.1033	0.0428	3	6.4282	1.8283	0.1763
03	85	11	14.62	0.8963		11	10.309	0.0463
04	101	14	17.372	0.6545		14	12.25	0.2500
07	82	11	14.104	0.6831		11	9.9455	0.1118
08	7	2	1.204			2	0.849
09	0	0	0			0	0
10	0	1	0			1	0
11	12	1	2.064			1	1.4554
12	6	2	1.032			2	0.7277
13	41	4	7.052	1.3209		4	4.9728	0.1903
14	13	0	2.236	2.2360		0	1.5767	1.5767
15	96	37	16.512	25.4214	<0.001
16	4	0	0.688			0	0.4851
(08/09/10/		6	4.988	0.2053		6	3.5173	1.7524
11/12/16)
Total	500	86	86	35.5208		49	49	5.7558

*The number of alleles expected in a sample of size 2n = 86, where n = 43, is derived from the number of alleles in a control sample of n = 250 (2n = 500).