Table 1 A selection of relevant studies showing the correlation between nitric oxide synthase (NOS) polymorphisms and cardiovascular events.
| Polymorphism | Clinical feature | Reference |
|---|---|---|
| G894T | Premature myocardial infarction | Antoniades et al,28 2006 |
| G894T | Abdominal aortic aneurysm | Fatini et al,27 2005 |
| T(−786)C | More advanced imbalance of autonomic activity in patients with congestive heart failure | Binkley et al,29 2005 |
| Asp298 | Coronary spastic angina | Ogimoto et al,34 2005 |
| 894 G→T | No evidence of a significant role in the development of CHD | Spence et al,35 2004 |
| Glu298→Asp T(786)→C | Early atherosclerosis No correlation with early atherosclerosis | Paradossi et al,25 2004 |
| 4a/4a 4a4a/−786CC | ACS, higher predisposition to ACS | Fatini et al,24 2004 |
| Glu298Asp T(786)→C intron‐4 | Increased risk of CHD, no significant association with CHD | Casas et al,30 2004 |
| Glu298Asp | Coronary spasm | Chang et al,31 2003 |
| Glu(298)→Asp T(786)→C Glu(298)→Asp/T(786) →C | Severe CHD higher risk | Colombo et al,32 2003 |
| T(786)→C | Severe ICA | Ghilardi et al,21 2002 |
| Glu298→Asp | Carotid atherosclerosis | Karvonen et al,20 2002 |
| Asp298 | Carotid atherosclerosis | Lembo et al,19 2001 |
| [(CA), polymorphism] in intron 13 | CHD | Stangl et al,33 2000 |
| 894 G→T | CHD and recent MI | Hingorani et al,37 1999 |
| Glu(298) →Asp | Susceptibility to AMI | Hibi et al,36 1998 |
| Glu298Asp | AMI | Shimasaki et al,38 1998 |
| Glu298asp E298D genotype | Carotid atherosclerosis | Wolff et al,26 2005 |
ACS, acute coronary syndrome; AMI, acute myocardial infarction; CHD, coronary heart disease; ICA, internal carotid artery; MI, myocardial infarction.