Fig 3.

HIV RNA viral load time profiles for 100 “virtual patients,” each of whom followed the non-adaptive treatment strategy of initiating treatment at time 0 and then permanently interrupting treatment at 6 months. All profiles are based on the same HIV dynamic model, similar to that depicted in Fig. 1. To create a virtual patient, values of the model parameters were randomly generated from a probability distribution representing how the model parameters vary in the population of patients. The system of ordinary differential equations was then solved using these values of the model parameters under this treatment strategy to yield the time profile for that patient.