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. Author manuscript; available in PMC: 2008 Apr 1.
Published in final edited form as: Dev Biol. 2006 Dec 23;304(1):420–432. doi: 10.1016/j.ydbio.2006.12.038

Figure 5.

Figure 5

Inhibition of Alk5 kinase activity does not affect significantly the rate of endothelial cell proliferation in AV canal explants but it does block EMT. (A). Alk5 kinase activity inhibited with 100 nM HTS does not significantly alter endothelial cell proliferation in explants derived from either stage 15 or 16. Stage 15 N= 10 and stage 16 N= 15. (B) Inhibition of Alk5 kinase activity by HTS at both stages 15 and16 reduces the number of mesenchymal cells in the collagen gel matrix. N=13 for each bar. * indicates p<0.01.