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. Author manuscript; available in PMC: 2007 Oct 5.
Published in final edited form as: Vaccine. 2007 Mar 30;25(22):4340–4344. doi: 10.1016/j.vaccine.2007.03.027

Figure 1. Effect of mannosylation on CD8+ MHC I-restricted lymphoproliferation.

Figure 1

BMDCs were cocultured with CD8-purified T cells from OT-I mice in the presence of the indicated antigens for 72 h before pulsing with [3H]-thymidine for 18 h. A. Comparison of E. coli and P. pastoris-derived antigens. Data are the mean ± SEM (n=3) of a representative of three independent experiments. *, p<0.01 (comparing ppOVA with ecOVA and ppOVAST with ecOVAST). B, Comparison of antigens with varying degrees of N- and O-linked mannosylation. Data are the mean ± SEM (n=15) of five independent experiments, each of which was performed in triplicate. *, p<0.01 (comparing ppOVANQ with ppOVA and ppOVASTNQ with ppOVAST). δ, p<0.05 (comparing ppOVASTNQ with ppOVANQ). δδ, p<0.01 (comparing ppOVAST with ppOVA).