Table 2.
Distribution of 91 MBC cases not mutated in BRCA genes and 261 male population controls according to the BRCA2 N372H genotype frequencies, stratified by age at diagnosis.
| Genotype | Cases n | % | Controls n | % | Co-dominant model OR 95% CI | Recessive model OR 95% CI |
| ≤60 years | ||||||
| N/N | 16 | 50.0 | 94 | 54.0 | ||
| N/H | 10 | 31.2 | 68 | 39.1 | 0.86 (0.37; 2.03) | |
| H/H | 6 | 18.8 | 12 | 6.9 | 2.94 (0.94; 9.15) | 3.12 (1.06; 9.16) |
| Total | 32 | 100.0 | 174 | 100.0 | ||
| >60 years | ||||||
| N/N | 32 | 54.2 | 33 | 37.9 | ||
| N/H | 21 | 35.6 | 39 | 44.8 | 0.56 (0.27; 1.15) | |
| H/H | 6 | 10.2 | 15 | 17.2 | 0.41 (0.14; 1.22) | 0.54 (0.20; 1.51) |
| Total | 59 | 100.0 | 87 | 100.0 |
Odds Ratios (OR) and 95% Confidence Intervals according to co-dominant and recessive models, estimated using logistic regression models. Interaction among between BRCA2 N372H genotype and age: ORinteraction = 0.17 (95%CI = 0.04–0.76); p = 0.02.