Table 4.
Distribution of 53 MBC with a time interval between diagnosis and interview ≤4 years and 261 male population controls according to the BRCA2 N372H genotype frequencies, stratified by age at diagnosis.
| Genotype | Cases n | % | Controls n | % | Co-dominant model OR 95% CI | Recessive model OR 95% CI |
| ≤60 years | ||||||
| N/N | 6 | 35.3 | 94 | 54.0 | ||
| N/H | 6 | 35.3 | 68 | 39.1 | 1.38 (0.43; 4.47) | |
| H/H | 5 | 29.4 | 12 | 6.9 | 6.53 (1.73; 24.69) | 5.63 (1.70;18.61) |
| Total | 17 | 100.0 | 174 | 100.0 | ||
| >60 years | ||||||
| N/N | 18 | 50.0 | 33 | 37.9 | ||
| N/H | 12 | 33.3 | 39 | 44.8 | 0.56 (0.24;1.34) | |
| H/H | 6 | 16.7 | 15 | 17.2 | 0.73 (0.24;2.22) | 0.96 (0.34;2.71) |
| Total | 36 | 100.0 | 87 | 100.0 |
Odds Ratios (OR) and 95% Confidence Intervals according to co-dominant and recessive models estimated using logistic regression models. Interaction between BRCA2 N372H genotype and age: ORinteraction = 0.17 (95%CI = 0.04–0.83); p = 0.03.