Table 5.

CTLA-4 allele counts and frequencies in breast cancer patients and healthy controls

SNP	Breast cancer (n = 117)		Healthy controls (n = 148)		P-value	Odds ratio (95% CI)
	Allele count (minor/major)	Allele frequency	Allele count (minor/major)	Allele frequency
CTLA-4 -1661G/A#	49/169	22.5%	39/257	13.2%	0.0057 a	1.91 (1.21–3.02)
CTLA-4 -658T/C†	6/224	2.6%	40/250	13.8%	0.0000082 b	0.17 (0.08–0.37)
CTLA-4 -318T/C	33/201	14.1%	19/277	6.4%	0.0031 c	2.39 (1.34–4.27)
CTLA-4 +49G/A	79/155	33.8%	116/180	39.2%	0.20
CTLA-4 CT60G/A	95/139	40.6%	92/204	31.1%	0.023	1.52 (1.06–2.17)

^# patients (n = 109), missing (n = 8); controls (n = 148), missing (n = 0)

^† patients (n = 115), missing (n = 2); controls (n = 145), missing (n = 3)

^aP = 0.031, ^bP = 0.00010 and ^cP = 0.017 after correcting the P-value for multiple testing by Haploview program using 10,000 permutations.