Table 6.
CTLA-4 haplotype frequencies in breast cancer patients and healthy controls
| CTLA-4 haplotype | Freq. | Breast cancer (n = 117) | Healthy controls (n = 148) | P-value | Odds ratio (95% CI) | ||||
| -1661 | -658 | -318 | +49 | CT60 | |||||
| A | C | C | G | A | 0.25 | 22.1% | 27.1% | 0.19 | |
| A | C | C | A | G | 0.22 | 25.5% | 19.3% | 0.089 | |
| A | C | C | A | A | 0.20 | 16.5% | 22.5% | 0.085 | |
| G | C | T | A | A | 0.062 | 8.1% | 4.6% | 0.081 | |
| A | C | C | G | G | 0.058 | 8.0% | 4.1% | 0.053 | |
| G | C | C | A | A | 0.052 | 6.5% | 4.2% | 0.22 | |
| A | T | C | G | A | 0.040 | 1.1% | 6.3% | 0.0026a | 0.17(0.05–0.54) |
| G | C | C | A | G | 0.033 | 3.9% | 2.8% | 0.50 | |
| A | T | C | A | A | 0.025 | 1.2% | 3.5% | 0.091 | |
| G | C | T | A | G | 0.016 | 2.2% | 1.1% | 0.32 | |
| A | T | C | A | G | 0.015 | 0.3% | 2.5% | 0.034 | 0.12(0.02–0.92) |
| A | C | T | A | A | 0.010 | 2.0% | 0.3% | 0.062 | |
aP = 0.012 after correcting the P-value for multiple testing by Haploview program using 10,000 permutations.