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. 2007 Sep 10;7:174. doi: 10.1186/1471-2407-7-174

Table 3.

Clinical, histologic, and image analysis factors affecting development of invasive disease by image analysis assessment

Clinical, histologic, and image analysis factors by assessment
Field 1 Field 2

Factorsa P-value Factorsa P-value

Assessment 1 Assessment 6
Densitometry (Minimum density) 0.001 Texture (Difference entropy) <0.001
Texture (Histogram mean) 0.02 Morphometry (Ellipse major axis) <0.001
Texture (Angular second moment) 0.001

Assessment 2 Assessment 7
Texture (Difference entropy) 0.01 Densitometry (Mean density) 0.001
Morphometry (Ellipse minor axis) 0.03 Texture (Difference entropy) 0.001
Texture (Diagonal moment) 0.04

Assessment 3 Assessment 8
Texture (Difference entropy) 0.01 Densitometry (Ellipse minor axis) 0.01
Densitometry (Maximum density) 0.003
Morphometry (Shape form factor) 0.04

Assessment 4 Assessment 9
Texture (Sum variance) 0.003 Texture (Difference entropy) <0.001
Texture (Difference entropy) <0.001 Texture (Contrast) <0.001
Texture (Second diagonal moment) <0.001 Morphometry (Ellipse major axis) 0.001
Nuclear grade 0.001 Age 0.02
Morphometry (Ellipse major axis) 0.01 Densitometry (Range density) 0.03

Assessment 5 10
Densitometry (Minimum density) <0.001 Morphometry (Shape form factor) 0.001
Measured margin <0.001 Texture (Histogram mean) 0.02
Texture (Variance) <0.001 Texture (Difference entropy) 0.01
Texture (Histogram Mean) <0.001 Measured margin 0.05
Texture (Contrast) 0.002

Field 1 Overall Field 2 Overall
Assessment 11 Assessment 12

Densitometry (Minimum density) 0.005 Texture (Difference entropy) <0.001
Texture (Difference entropy) 0.01 Discriminant classification function <0.001
Texture (Diagonal moment) 0.04 Parenchymal involvement 0.001
Both Fields Overall – Assessment 13
Texture (Difference entropy) p < 0.001
Texture (Contrast) p < 0.001
Texture (Peak transition probability) p = 0.01
Densitometry (Range density) p = 0.004
Measured margin p = 0.05

a Factors significantly (p ≤ 0.05) associated with development of invasive disease, in the order entered into the step-wise forward Cox regression models.

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