Table 3.
Clinical, histologic, and image analysis factors affecting development of invasive disease by image analysis assessment
| Clinical, histologic, and image analysis factors by assessment | |||
| Field 1 | Field 2 | ||
| Factorsa | P-value | Factorsa | P-value |
| Assessment 1 | Assessment 6 | ||
| Densitometry (Minimum density) | 0.001 | Texture (Difference entropy) | <0.001 |
| Texture (Histogram mean) | 0.02 | Morphometry (Ellipse major axis) | <0.001 |
| Texture (Angular second moment) | 0.001 | ||
| Assessment 2 | Assessment 7 | ||
| Texture (Difference entropy) | 0.01 | Densitometry (Mean density) | 0.001 |
| Morphometry (Ellipse minor axis) | 0.03 | Texture (Difference entropy) | 0.001 |
| Texture (Diagonal moment) | 0.04 | ||
| Assessment 3 | Assessment 8 | ||
| Texture (Difference entropy) | 0.01 | Densitometry (Ellipse minor axis) | 0.01 |
| Densitometry (Maximum density) | 0.003 | ||
| Morphometry (Shape form factor) | 0.04 | ||
| Assessment 4 | Assessment 9 | ||
| Texture (Sum variance) | 0.003 | Texture (Difference entropy) | <0.001 |
| Texture (Difference entropy) | <0.001 | Texture (Contrast) | <0.001 |
| Texture (Second diagonal moment) | <0.001 | Morphometry (Ellipse major axis) | 0.001 |
| Nuclear grade | 0.001 | Age | 0.02 |
| Morphometry (Ellipse major axis) | 0.01 | Densitometry (Range density) | 0.03 |
| Assessment 5 | 10 | ||
| Densitometry (Minimum density) | <0.001 | Morphometry (Shape form factor) | 0.001 |
| Measured margin | <0.001 | Texture (Histogram mean) | 0.02 |
| Texture (Variance) | <0.001 | Texture (Difference entropy) | 0.01 |
| Texture (Histogram Mean) | <0.001 | Measured margin | 0.05 |
| Texture (Contrast) | 0.002 | ||
| Field 1 Overall | Field 2 Overall | ||
| Assessment 11 | Assessment 12 | ||
| Densitometry (Minimum density) | 0.005 | Texture (Difference entropy) | <0.001 |
| Texture (Difference entropy) | 0.01 | Discriminant classification function | <0.001 |
| Texture (Diagonal moment) | 0.04 | Parenchymal involvement | 0.001 |
| Both Fields Overall – Assessment 13 | |||
| Texture (Difference entropy) | p < 0.001 | ||
| Texture (Contrast) | p < 0.001 | ||
| Texture (Peak transition probability) | p = 0.01 | ||
| Densitometry (Range density) | p = 0.004 | ||
| Measured margin | p = 0.05 | ||
a Factors significantly (p ≤ 0.05) associated with development of invasive disease, in the order entered into the step-wise forward Cox regression models.