Table 2.

Reversible gene expression upon smoking cessation related to xenobiotic metabolism and DNA adduct formation (genes in bold have not been previously associated with smoking)

Tag	Gene Symbol	Gene Name	CS Mean*	FS Mean*	NS Mean*	P-Value (CVsF)
GGCCCAGGCC	ALDH3A1	Aldehyde dehydrogenase 3 family, memberA1	4355	313	261	0.00002
TTAAAAATTC	ADH7	Alcohol dehydrogenase 7 (class IV)	899	145	130	0.00002
AGGTCTGCCA***	AKR1C2	Aldo-keto reductase family 1, member C2	547	116	74	0.00002
AATGCTTTTA	CYP1B1	Cytochrome P450, family 1, subfamily B, polypeptide 1	204	13	0	0.00002
TTGGAATCCA	STAU2	Staufen, RNA binding protein, homolog 2 (Drosophila)	67	17	23	0.00002
TTATCAAATC	NQO1	NAD(P)H dehydrogenase, quinone 1	809	202	149	0.00003
CAAATAAACC	PIR	Pirin (iron-binding nuclear protein)	260	47	43	0.00003
GGCCCCATTT	CBR1	Carbonyl reductase 1	144	31	24	0.00003
TATTTTTGTT	TXNRD1	Thioredoxin reductase 1	250	88	78	0.00006
GGTGGTGTCT	GPX2	Glutathione peroxidase 2 (gastrointestinal)	384	40	46	0.00011
TATTTTTGAA	DRB1	Developmentally regulated RNA-binding protein 1	204	32	22	0.00011
TGGGAGTGGG**	NMNAT2	Nicotinamide nucleotide adenylyltransferase 2	175	17	9	0.00011
CAAGACCAGT	GSTA2	Glutathione S-transferase A2	1436	485	528	0.00019
GCTTGAATAA	AKR1B10	Aldo-keto reductase family 1, member B10 (aldose reductase)	332	10	15	0.0003
GTGCAGGGAG	SPDEF	SAM pointed domain containing ets transcription factor	239	64	50	0.0003
GGAGGCTTCC	MECR	Mitochondrial trans-2-enoyl-CoA reductase	85	26	22	0.0003
GTGATGTAAG	SRXN1	Sulfiredoxin 1 homolog (S. cerevisiae)	63	14	11	0.0003
TATGCTTTAA	NT5DC1	5'-nucleotidase domain containing 1	59	23	24	0.0003
GAACGCCTAA	DPYSL2	Dihydropyrimidinase-like 2	1	21	23	0.0004
TTTTCTGAAA	TXN	Thioredoxin	698	326	212	0.00048
CTTGCATAAG	CYP1A1	Cytochrome P450, family 1, subfamily A, polypeptide 1	89	2	0	0.00048
GCAAGAAGAG	ALDH3A1	Aldehyde dehydrogenase 3 family, memberA1	77	10	2	0.00048
AGAACAAAAC	PRDX1	Peroxiredoxin 1	1043	418	510	0.00071
AAATATTTAA	SLC35A3	Solute carrier family 35, member A3	47	14	19	0.00071
CGGCTGAATT	PGD	Phosphogluconate dehydrogenase	252	104	80	0.00106
CTTATCAGTA	BTBD7	BTB (POZ) domain containing 7	94	22	2	0.00106
AAGAGTTTTG	AKR1B1	Aldo-keto reductase family 1, member B1 (aldose reductase)	25	5	6	0.00141
GCTGAGATGA**	CYP4F11	Cytochrome P450, family 4, subfamily F, polypeptide 11	22	6	2	0.00141
GGCGCCTCCT	TALDO1	Transaldolase 1	232	76	94	0.00152
GACACAGCAA	ENTPD8	Ectonucleoside triphosphate diphosphohydrolase 8	24	3	2	0.00159
CAGTCTAAAA	UCHL1	Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	92	4	0	0.00197
ACATCCTAGG	ALDH1A1	Aldehyde dehydrogenase 1 family, member A1	60	28	30	0.00216
TTAGAAGGAA	NQO1	NAD(P)H dehydrogenase, quinone 1	41	14	9	0.00216
AGGTCTACCA	AKR1C2	Aldo-keto reductase family 1, member C2	270	32	8	0.00292
ATTAGGCCTG	TXNRD1	Thioredoxin reductase 1	51	19	17	0.00297
GAGAGCTTTG	AKR1C3	Aldo-keto reductase family 1, member C3	149	21	22	0.00298
TACGCTTGGT	CYB5R1	Cytochrome b5 reductase 1	68	32	30	0.00298
CACTGCCTTG	FTH1	Ferritin, heavy polypeptide 1	59	23	17	0.00298
CTGCTGCACT	GSR	Glutathione reductase	126	54	50	0.0041
GGCAAAATTA	SLC35A3	Solute carrier family 35, member A3	73	32	35	0.0041
ACCTTGGGGT	NQO1	NAD(P)H dehydrogenase, quinone 1	73	19	6	0.0041
AATGTTCAGG	COQ6	Coenzyme Q6 homolog, monooxygenase (yeast)	29	12	4	0.00708
CACTGACCAG	NOD27	Nucleotide-binding oligomerization domains 27	31	10	0	0.00927
CTCGGAGGCC	SEPX1	Selenoprotein X, 1	71	32	28	0.00956
CTCCAAAAAA	CPSF2	Cleavage and polyadenylation specific factor 2, 100 kDa	118	44	14	0.02013
AATGGAAACT	GCLM	Glutamate-cysteine ligase, modifier subunit	34	16	9	0.03186

*Mean in tags per million (TPM)

** Changed mapping with TAGMapper [56]

***Tag maps with equal reliability to AKR1C1