Figure 3. Graphic Representation of the Recombination Patterns of the CB1 Gene in the Different Conditional Mutant Lines.

Circles represent “domains“ of recombination. Intersection areas represent overlapping between the different recombination patterns. CaMK-CB1 ^−/− mice (light blue) present the widest recombination of CB1, which is partially overlapping with the one of GABA-CB1 ^−/− mice (red-blue overlapping, i.e., principal striatal GABAergic neurons). GABA-CB1 ^−/− mice (red) present a specific deletion of GABAergic neurons, which are specific of this line concerning cortical GABAergic interneurons (non-overlapping red area), but overlap with CaMK-CB1 ^−/− and D1-CB1 ^−/− mice in the striatum. Glu-CB1 ^−/− recombination (green) fully overlap only with CaMK-CB1 ^−/− (glutamatergic cortical neurons). D1-CB1 ^−/− mice (yellow) share with GABA-CB1 ^−/− and CaMK-CB1 ^−/− the deletion in the majority of striatal neurons and with Glu-CB1 ^−/− and CaMK-CB1 ^−/− the deletion in glutamatergic layer VI neocortical neurons.

Proportions of overlapping areas are not quantitative and are not representative of cell numbers. Descriptive expression data are collected from previous publications [27,28] and from the present study.