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. 2007 Oct 9;5(10):e269. doi: 10.1371/journal.pbio.0050269

Figure 4. Effect of THC on Locomotor Activity of Different CB1 Mutant Mice.

Figure 4

Horizontal locomotor activity was recorded for 15 min, 60 min after the injection of 10 mg/kg THC or vehicle. Values were recorded in cm and normalized to vehicle-treated wild-type animals of each mutant line (100%). *, **, ***; p < 0.05, p < 0.01, p < 0.001, respectively. (two-way ANOVA, followed by Newman-Keuls post-hoc test). Note the normal effect of the drug in GABA-CB1 −/− (A), the impaired effect in CaMK-CB1 −/− (B), and in Glu-CB1 −/− (C), and the normal effect in D1-CB1 −/− mice (D). For D1-CB1 −/−, see text for a slight impairment in the relative effect of THC. See Materials and Methods for number of animals in each group.