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. Author manuscript; available in PMC: 2008 Jul 1.
Published in final edited form as: Methods. 2007 Jul;42(3):227–233. doi: 10.1016/j.ymeth.2007.02.020

Figure 4.

Figure 4

A structural model for the ERK2/pTpY-MKP3 complex. ERK2/pTpY was shown in gray, MKP3 N-terminal domain in green, and MKP3 C-terminal domain in blue. The common docking (CD) and substrate-binding (SB) site were colored yellow and cyan, respectively, and pTyr185 was colored pink. The kinase interaction motif (KIM) peptide, the N-β4-α4 loop, and the FXFP peptide were highlighted in red. MKP3 active site residues Asp262, Cys293, and Arg299 were also depicted as stick model in atomic colors.