Table 2. Measures of cardiovascular structure and function.
CON (n=617) | HTN (n=719) | HfnlEF (n=244) | ||
---|---|---|---|---|
LV structure | ||||
| ||||
Teichholz | 110.6±23.6 | 113.3±26.1 | 110.2±32.6 | |
EDV, ml | Area-length | 123.2±30.3 | 125.9±32.9 | 119.4±39.3† |
Doppler | 134.4±31.4 | 141.1±35.5 | 132.8±37.7† | |
Teichholz | 60.6±10.9 | 59.7±12.2 | 56.4±14.4*† | |
EDVI, ml/m2 | Area-length | 66.6±12.3 | 64.9±13.9 | 60.9±16.1† |
Doppler | 72.5±12.9 | 72.2±15.5 | 68.1±16.6*† | |
Stroke volume index, ml/m2 | 45.8±7.5 | 46.3±9.5 | 42.3±10.0*† | |
Cardiac index, l/min/m2 | 2.94±0.57 | 3.04±0.70 | 2.95±0.79† | |
LV mass, g | 164.2±38.8 | 195.0±53.2* | 200.4±67.1* | |
LV mass index, g/m2 | 88.8±16.3 | 100.2±22.7* | 102.1±29.0* | |
LV mass/EDV, mg/ml | 1.50±0.28 | 1.75±0.39* | 1.85±0.47* | |
Relative wall thickness | 0.38±0.06 | 0.42±0.07* | 0.45±0.10* | |
% LV hypertrophy | 18% | 40%* | 42%* | |
% Normal geometry | 66 | 39* | 31* | |
% Concentric remodeling | 16 | 21 | 27 | |
% Concentric hypertrophy | 5 | 21* | 26* | |
% Eccentric hypertrophy | 13 | 19 | 16 | |
| ||||
Vascular function | ||||
Effective arterial elastance (Ea), mmHg/ml | 1.30±0.30 | 1.50±0.41* | 1.53±0.43* | |
Systemic vascular resistance index, dyne.s.cm−5.m2 | 2424±521 | 2703±657* | 2588±873* | |
Arterial compliance, ml/mmHg | 1.86±0.58 | 1.45±0.55* | 1.41±0.93* | |
| ||||
LV systolic function | ||||
End-systolic elastance (Ees), mmHg/ml | 1.99±0.59 | 2.30±0.80* | 2.39±0.87* | |
Ees*LV mass | 319.7±96.4 | 439.6±163.7* | 461.8±209.7* | |
Ees*EDV | 215.5±60.7 | 256.3±86.3* | 254.0±105.3* | |
Ea/Ees | 0.68±0.13 | 0.68±0.17 | 0.69±0.22 | |
| ||||
LV diastolic function | ||||
E, m/s | 0.660±0.131 | 0.671±0.169* | 0.979±0.347*† | |
A, m/s | 0.561±0.161 | 0.722±0.203* | 0.848±0.267*† | |
E/A ratio | 1.25±0.38 | 0.99±0.37* | 1.21±0.69*† | |
Deceleration time, ms | 222±33 | 239±43 | 208±54*† | |
e′, m/s | 0.094±0.035 | 0.077±0.039* | 0.060±0.021*† | |
τ, ms | 35.2±23.4 | 46.8±26.0* | 58.1±14.3*† | |
E/e’ ratio | 7.55±2.29 | 9.43±3.32* | 18.43±9.65*† | |
LV end-diastolic pressure (EDP), mmHg | 16.5±1.4 | 17.6±2.0* | 22.9±5.7*† | |
Diastolic stiffness constant (β) | 5.96±0.06 | 6.05±0.41* | 7.09±3.55*† | |
EDVI20, ml/m2 | 61.7±11.4 | 59.7±11.9* | 55.7±14.5*† | |
EDP/EDV, mmHg/ml | 0.16±0.04 | 0.16±0.05 | 0.23±0.11*† |
Data are mean ± SD; Comparisons adjusted for age and sex, as well as body surface area (BSA) where appropriate;
p<0.05 vs CON;
p<0.05 vs HTN; LV, left ventricular; EDV, end-diastolic volume; I, indexed to BSA