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. Author manuscript; available in PMC: 2007 Oct 17.
Published in final edited form as: Circulation. 2007 Apr 2;115(15):1982–1990. doi: 10.1161/CIRCULATIONAHA.106.659763

Table 2. Measures of cardiovascular structure and function.

CON (n=617) HTN (n=719) HfnlEF (n=244)
LV structure

Teichholz 110.6±23.6 113.3±26.1 110.2±32.6
EDV, ml Area-length 123.2±30.3 125.9±32.9 119.4±39.3
Doppler 134.4±31.4 141.1±35.5 132.8±37.7
Teichholz 60.6±10.9 59.7±12.2 56.4±14.4*
EDVI, ml/m2 Area-length 66.6±12.3 64.9±13.9 60.9±16.1
Doppler 72.5±12.9 72.2±15.5 68.1±16.6*
Stroke volume index, ml/m2 45.8±7.5 46.3±9.5 42.3±10.0*
Cardiac index, l/min/m2 2.94±0.57 3.04±0.70 2.95±0.79
LV mass, g 164.2±38.8 195.0±53.2* 200.4±67.1*
LV mass index, g/m2 88.8±16.3 100.2±22.7* 102.1±29.0*
LV mass/EDV, mg/ml 1.50±0.28 1.75±0.39* 1.85±0.47*
Relative wall thickness 0.38±0.06 0.42±0.07* 0.45±0.10*
% LV hypertrophy 18% 40%* 42%*
% Normal geometry 66 39* 31*
% Concentric remodeling 16 21 27
% Concentric hypertrophy 5 21* 26*
% Eccentric hypertrophy 13 19 16

Vascular function
Effective arterial elastance (Ea), mmHg/ml 1.30±0.30 1.50±0.41* 1.53±0.43*
Systemic vascular resistance index, dyne.s.cm−5.m2 2424±521 2703±657* 2588±873*
Arterial compliance, ml/mmHg 1.86±0.58 1.45±0.55* 1.41±0.93*

LV systolic function
End-systolic elastance (Ees), mmHg/ml 1.99±0.59 2.30±0.80* 2.39±0.87*
Ees*LV mass 319.7±96.4 439.6±163.7* 461.8±209.7*
Ees*EDV 215.5±60.7 256.3±86.3* 254.0±105.3*
Ea/Ees 0.68±0.13 0.68±0.17 0.69±0.22

LV diastolic function
E, m/s 0.660±0.131 0.671±0.169* 0.979±0.347*
A, m/s 0.561±0.161 0.722±0.203* 0.848±0.267*
E/A ratio 1.25±0.38 0.99±0.37* 1.21±0.69*
Deceleration time, ms 222±33 239±43 208±54*
e′, m/s 0.094±0.035 0.077±0.039* 0.060±0.021*
τ, ms 35.2±23.4 46.8±26.0* 58.1±14.3*
E/e’ ratio 7.55±2.29 9.43±3.32* 18.43±9.65*
LV end-diastolic pressure (EDP), mmHg 16.5±1.4 17.6±2.0* 22.9±5.7*
Diastolic stiffness constant (β) 5.96±0.06 6.05±0.41* 7.09±3.55*
EDVI20, ml/m2 61.7±11.4 59.7±11.9* 55.7±14.5*
EDP/EDV, mmHg/ml 0.16±0.04 0.16±0.05 0.23±0.11*

Data are mean ± SD; Comparisons adjusted for age and sex, as well as body surface area (BSA) where appropriate;

*

p<0.05 vs CON;

p<0.05 vs HTN; LV, left ventricular; EDV, end-diastolic volume; I, indexed to BSA

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