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. Author manuscript; available in PMC: 2008 Jun 7.
Published in final edited form as: Neuron. 2007 Jun 7;54(5):801–812. doi: 10.1016/j.neuron.2007.05.020

Figure 7.

Figure 7

RIM1α and PKA control GABA release and inhibitory synaptic plasticity in basolateral amygdala. (A) WIN depressed mIPSC frequency in BLA (n = 5), an effect blocked by CB1 receptor antagonists (5 μM AM 251, n = 2; 5 μM SR131716, n = 2). Sample traces are shown on the right. (B) WIN-mediated depression was blocked by H-89 (n =5). (C) LTD induction was blocked in RIM1α KO mice (11 cells, 5 mice), compared to their WT littermates (9 cells, 6 mice). (D) LTD induced pharmacologically by DHPG (50 µM, 15 min) was also abolished in RIM1α KO mice compared to WT mice (n = 7, 3 WT mice and n = 6, 4 KO mice).