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. 2001 Jun 15;107(12):1563–1569. doi: 10.1172/JCI11234

Figure 3.

Figure 3

Chronic acid feeding causes a more severe acidosis in Tg/Tg:ETB–/– mice. Tg/Tg:ETB+/+, Tg/Tg:ETB+/–, and Tg/Tg:ETB–/– mice were fed control or acid diets (metabolic acidosis) for 7 days. Arterial blood gases were measured, and the measured pH and pCO2 were used to calculate blood HCO3– concentration. (a) Blood HCO3– levels. AP < 0.05 versus control (b). Acid-induced change in blood HCO3– levels. BP = 0.06, CP < 0.05 versus Tg/Tg:ETB–/–; DP = NS versus Tg/Tg:ETB+/–. Tg/Tg:ETB+/+, n = 12; Tg/Tg:ETB+/–, n = 12; and Tg/Tg:ETB–/–, n = 14.