Figure 1.
Computer prediction of RNA secondary structure of RSV mRNAs. (A) Predicted secondary structure of a 3′region of the RSV M2 mRNA (nucleotides 8235–8560), (B) Structure of a 5′-region of the RSV L mRNA (nucleotides 8490–8800). 2–5A-antisense binding sites are indicated by thick, black bands. The entire M2 mRNA contains nucleotides 7599–8561, and the entire L mRNA contains nucleotides 8490–15070. Small black dots are shown in the diagram after every 20 nucleotides beginning with nucleotide 8240 (A) and beginning with nucleotide 8500 (B). ΔG values were −33.6 and −39.3 kcal per mol for the structures shown in (A) and (B), respectively.