Table 1.
Effects of aging on liver microcirculation
| 0.8 Mo | 3.3 Mo | 14 Mo | 27 Mo | |
|---|---|---|---|---|
| Laser Doppler flow (AU) | 403.4±21.2 | 343.8±21.3 | 347.0±14.5 | 261.7±21.4a,b |
| Perfused sinusoids(/field) | ||||
| Periportal | 4.8±0.1 | 4.9±0.1 | 4.6±0.1 | 4.1±0.1a,b,c |
| Centrilobular | 4.4±0.1 | 4.5±0.1 | 4.3±0.1 | 4.0±0.1a,b,c |
| Swollen endothelial cells (/field) | ||||
| Periportal | 0.3±0.1 | 0.2±0.0 | 0.3±0.1a,b | 1.0±0.0a,b |
| Centrilobular | 0.3±0.1 | 0.2±0.0 | 0.5±0.0a,b | 0.6±0.1a,b |
| Adherent leukocytes (/100 μm) | ||||
| Periportal | 0.06±0.01 | 0.03±0.01 | 0.04±0.01 | 0.29±0.01a,b,c |
| Centrilobular | 0.09±0.02 | 0.05±0.01 | 0.04±0.01 | 0.21±0.01a,b,c |
| Kupffer cell phagocytic activity | ||||
| Periportal | 0.99±0.06 | 0.69±0.05 | 0.66±0.04a | 0.87±0.05b,c |
| Centrilobular | 0.52±0.01 | 0.29±0.06a | 0.21±0.06a | 0.21±0.03a |
| Diameter of the sinusoids (μm) | ||||
| Periportal | 5.9±0.1 | 5.6±0.1 | 5.7±0.1 | 5.4±0.0a |
| Centrilobular | 7.2±0.1 | 6.8±0.1a | 6.6±0.1a | 6.5±0.2a |
Data are the means ± SEM from 6–8 animals per group.
a
P<0.05 vs. 0.8 month old mice,
b
P<0.05 vs. 3.3 month old mice,
c
P,0.05 vs. 14 month old mice.s